It's the hottest and most sought-after rune currently. It is neither easy to create or get access to the appropriate altar RuneScape Gold. However, high turnout per hour is well worth the risk. Level 99 of Skill Runecrafting and complete Dragon Slayer II quest (required skill levels 75 magic, 70 smithing, 64 Crafting, 68 Mining 60 Agility Thieving 50 Construction 50 Hitpoints).
While it's a bit of a challenge by itself, here comes the biggest issue - Wrath Altar is accessed via Myth's Guild by climbing down Mythic Statue and then running through caves filled with dragons that are chromatic. It's worth it. A side note: altar can't be accessed via Abyss and neither the output could be increased.
It is necessary to have Fletching proficiency level 70 and yew wood logs (Woodcutting skill level 60) to cut the yew longbow (u) off of the wood, and then stringing the bow (Crafting proficiency level of 10,) that you can string it. Making the bow as well as stringing it yield Fletching knowledge.
Skill Herblore up to 25 in order clean Grimy Ranarr Weed it is available at combat skill level 13 Chaos Druids (which is an excellent cross-gold making opportunity, since Chaos druids can be mined for many valuable items) Continue to work on it until you reach level 30 in Herblore skill when you will gain the ability to make unfinished Ranarr potions buy osrs infernal cape. Once you have it, place it on the Grand Exchange and hope for enormous gains.